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Page 1
RNA-guided DNA insertion with CRISPR-associated transposases.
Strecker J, Ladha A, Gardner Z, Schmid-Burgk JL, Makarova KS, Koonin EV, Zhang F. Strecker J, et al. Science. 2019 Jul 5;365(6448):48-53. doi: 10.1126/science.aax9181. Epub 2019 Jun 6. Science. 2019. PMID: 31171706 Free PMC article.
Here we characterize a CRISPR-associated transposase from cyanobacteria Scytonema hofmanni (ShCAST) that consists of Tn7-like transposase subunits and the type V-K CRISPR effector (Cas12k). ...
Here we characterize a CRISPR-associated transposase from cyanobacteria Scytonema hofmanni (ShCAST) that consists of Tn7-like …
Hofmannolin, a cyanopeptolin from Scytonema hofmanni PCC 7110.
Matern U, Oberer L, Erhard M, Herdman M, Weckesser J. Matern U, et al. Phytochemistry. 2003 Nov;64(6):1061-7. doi: 10.1016/s0031-9422(03)00467-9. Phytochemistry. 2003. PMID: 14568072
Two depsipeptide metabolites, scyptolin A and B, were reported recently from the axenically grown terrestrial cyanobacterium Scytonema hofmanni PCC 7110. A related, novel depsipeptide was isolated from this Scytonema and designated hofmannolin. ...
Two depsipeptide metabolites, scyptolin A and B, were reported recently from the axenically grown terrestrial cyanobacterium Scytonema …
Isolation and structure determination of a proteasome inhibitory metabolite from a culture of Scytonema hofmanni.
Shim SH, Chlipala G, Orjala J. Shim SH, et al. J Microbiol Biotechnol. 2008 Oct;18(10):1655-8. J Microbiol Biotechnol. 2008. PMID: 18955814 Free PMC article.
A proteasome inhibitor was screened from an extract of the culture of Scytonema hofmanni on the basis of its inhibitory activity, which led to the isolation of nostodione A with an IC(50) value of 50 microM. ...
A proteasome inhibitor was screened from an extract of the culture of Scytonema hofmanni on the basis of its inhibitory activi …
Target site selection and remodelling by type V CRISPR-transposon systems.
Querques I, Schmitz M, Oberli S, Chanez C, Jinek M. Querques I, et al. Nature. 2021 Nov;599(7885):497-502. doi: 10.1038/s41586-021-04030-z. Epub 2021 Nov 10. Nature. 2021. PMID: 34759315 Free PMC article.
Here we report cryo-electron microscopic structures of a Cas12k-guide RNA-target DNA complex and a DNA-bound, polymeric TnsC filament from the CRISPR-associated transposon system of the photosynthetic cyanobacterium Scytonema hofmanni. The Cas12k complex structure r …
Here we report cryo-electron microscopic structures of a Cas12k-guide RNA-target DNA complex and a DNA-bound, polymeric TnsC filament from t …
Antifungal compounds from cyanobacteria.
Shishido TK, Humisto A, Jokela J, Liu L, Wahlsten M, Tamrakar A, Fewer DP, Permi P, Andreote AP, Fiore MF, Sivonen K. Shishido TK, et al. Mar Drugs. 2015 Apr 13;13(4):2124-40. doi: 10.3390/md13042124. Mar Drugs. 2015. PMID: 25871291 Free PMC article.
HAN21/1, Anabaena cf. cylindrica PH133, Nostoc sp. HAN11/1 and Scytonema sp. HAN3/2. To our knowledge, this is the first description of Anabaena strains that produce scytophycins. ...In addition, three cyanobacterial strains, Fischerella sp. CENA 298, Scytonema h …
HAN21/1, Anabaena cf. cylindrica PH133, Nostoc sp. HAN11/1 and Scytonema sp. HAN3/2. To our knowledge, this is the first description …
A versatile Cas12k-based genetic engineering toolkit (C12KGET) for metabolic engineering in genetic manipulation-deprived strains.
Cui Y, Dong H, Tong B, Wang H, Chen X, Liu G, Zhang D. Cui Y, et al. Nucleic Acids Res. 2022 Aug 26;50(15):8961-8973. doi: 10.1093/nar/gkac655. Nucleic Acids Res. 2022. PMID: 35920322 Free PMC article.
Therefore, it is crucial to develop host-independent gene editing tools that can be used for genetic manipulation-deprived strains. The Tn7-like transposon from Scytonema hofmanni has been shown to mediate homologous recombination-independent genomic integration aft …
Therefore, it is crucial to develop host-independent gene editing tools that can be used for genetic manipulation-deprived strains. The Tn7- …
Scyptolin A and B, cyclic depsipeptides from axenic cultures of Scytonema hofmanni PCC 7110.
Matern U, Oberer L, Falchetto RA, Erhard M, König WA, Herdman M, Weckesser J. Matern U, et al. Phytochemistry. 2001 Dec;58(7):1087-95. doi: 10.1016/s0031-9422(01)00400-9. Phytochemistry. 2001. PMID: 11730873
Two novel cyclic depsipeptides were isolated from axenic cultures of the terrestrial cyanobacterium Scytonema hofmanni PCC 7110 and designated scyptolin A and B. Amino acid analyses in context with mass and 1H/13C NMR spectroscopies revealed a composition typical fo …
Two novel cyclic depsipeptides were isolated from axenic cultures of the terrestrial cyanobacterium Scytonema hofmanni PCC 711 …
Isolation of chlorine-containing antibiotic from the freshwater cyanobacterium Scytonema hofmanni.
Mason CP, Edwards KR, Carlson RE, Pignatello J, Gleason FK, Wood JM. Mason CP, et al. Science. 1982 Jan 22;215(4531):400-2. doi: 10.1126/science.6800032. Science. 1982. PMID: 6800032
Scytonema hofmanni, a filamentous freshwater cyanobacterium (blue-green alga), produces secondary metabolites which inhibit the growth of other cyanobacteria and green algae. ...This assay procedure has led to the isolation and characterization of an antibiotic (nam …
Scytonema hofmanni, a filamentous freshwater cyanobacterium (blue-green alga), produces secondary metabolites which inhibit th …
Repurposing CRISPR RNA-guided integrases system for one-step, efficient genomic integration of ultra-long DNA sequences.
Cheng ZH, Wu J, Liu JQ, Min D, Liu DF, Li WW, Yu HQ. Cheng ZH, et al. Nucleic Acids Res. 2022 Jul 22;50(13):7739-7750. doi: 10.1093/nar/gkac554. Nucleic Acids Res. 2022. PMID: 35776123 Free PMC article.
Herein, using Shewanella oneidensis MR-1 as a model, we developed an optimized CRISPR-associated transposase from cyanobacteria Scytonema hofmanni (ShCAST system), which enables programmable, RNA-guided transposition of ultra-long DNA sequences (30 kb) onto bacteria …
Herein, using Shewanella oneidensis MR-1 as a model, we developed an optimized CRISPR-associated transposase from cyanobacteria Scytonema …
Mechanistic details of CRISPR-associated transposon recruitment and integration revealed by cryo-EM.
Park JU, Tsai AW, Chen TH, Peters JE, Kellogg EH. Park JU, et al. Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2202590119. doi: 10.1073/pnas.2202590119. Epub 2022 Aug 1. Proc Natl Acad Sci U S A. 2022. PMID: 35914146 Free PMC article.
Using cryo-electron microscopy (cryo-EM) structure determination, we reveal the conformation of TnsB during transposon integration for the type V-K CAST system from Scytonema hofmanni (ShCAST). Our structure of TnsB is a tetramer, revealing strong mechanistic relati …
Using cryo-electron microscopy (cryo-EM) structure determination, we reveal the conformation of TnsB during transposon integration for the t …
21 results